I don't know that I've ever road tripped the deuce without our travel trailer strapped on the back. Most recent was driving from Florida to California, 2000 miles in all with the trailer on back.
I've got factory air suspension and my buddy who made the trip with me was amazed at how smooth and controlled the deuce was with a trailer behind it. I'd try to prepare him for how slow the trip would be as the truck wants to heat up at highway speeds pulling that much weight, but we made the drive in late October and it ran extremely well.
This was an uneventful trip, always tons of room for the wife and 3 kids, but again, all their junk is usually in the trailer---that's the way to travel. Pull over when you get tired or hungry and hang out in the trailer or park it for the night.
The truck has always been a blast to drive, but you gotta know if you're going to step up your going to put gas in it. There's no bitching about it, just a fact of life you go into when you buy one. I was getting 5.8 to just over 6 mpg pulling the trailer for those 2000 miles, that's about $1000 in gas at around $3 a gallon. I never regretted it, in this truck it's about living life and enjoying the world.